About Karl
German
Native or bilingual
Romanian
Native or bilingual
English
Native or bilingual
Italian
Basic
Experience
- Quint HealthcareFounder and ConsultantMEDICALJanuary 2014 - Today (12 years and 7 months)Fürth, GermanyQuint Healthcare is a specialised healthcare consultancy with a focus on innovation projects in clinical medicine, life sciences, medical devices and digital health. We work with start-ups and mature companies to design, manage and co-create innovative products, solutions and services, advise on regulatory affairs, plan and manage clinical validation studies and support market entry.
- Institute of Pathology, University Hospital Erlangen (UHE)Resident Physician, Researcher, Biological Security Officer (BBS)MEDICALNovember 2012 - August 2013 (9 months)Erlangen, GermanyResident of pathology, worked in tissue diagnostics, surgical pathology and research projects. Received a grant to set up a research laboratory.
- Institute for Surgical Research, Philipps University of MarburgHead of Laboratory, Project Leader GenTSVMEDICALNovember 2009 - October 2012 (2 years and 11 months)Marburg, Germany
Leadership & organizational responsibilities
- re-established a multidisciplinary translational research lab (in cooperation with the institute director)
- complete digitization of the lab’s workflows, including cell culture and histological/tissue analysis, digital
- pathology and molecular biological methods
- in charge of supervising day-to-day research operations, incl. budget responsibilities
- applied for certification and established Biological Safety Level (BSL) I and II laboratories
- deputy Gene Technology Safety Officer / Project Leader
Scientific projects
- Liver cancer / Hepatocellular Carcinoma (HCC)
- miRNA regulation in HCC
- alternative apoptotic pathways in HCC
- biomarker studies of histone deacetylases (HDAC) and therapy using HDAC inhibitors in HCC
- endoplasmic reticulum stress in HCC
- epithelial mesenchymal transition in HCC
Clinical study in HCC
- Temsirolimus + Sorafenib in Advanced Hepatocellular Carcinoma (HCC) (Phase 1/2, NCT01335074, EudraCT: 2009-017749-69)
Pancreatic cancer
- influence of tumor stem cells and epithelial mesenchymal transition on drug resistance in PDAC
- (pancreatic ductal adenocarcinoma)
- tyrosine-kinase inhibitors in Gemcitabine-resistent PDAC
- translational surgical research
- Laser-based lung and hepatic metastasis resection
- embryonic (stem cell) transcription factors in neuroendocrine tumors of the ileum
Glioblastoma multiforme
- expression profiling of Sphingosine-kinase signalling pathways in glioblastoma multiforme in vitro and in patient tumor samples
- glioblastoma multiforme therapy with fingolimod (FTY720) and roscovitine
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Education
- Master Student of PhilosophyIstitutoMaster Student of Philosophy
- University Certificate "Medical Product Regulation"University of Erlangen2020University Certificate "Medical Product Regulation"